利用交联寡核苷酸对双螺旋DNA组装体的控制
Control of a double helix DNA assembly by use of cross-linked oligonucleotides.
作者信息
Endo Masayuki, Majima Tetsuro
机构信息
Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
出版信息
J Am Chem Soc. 2003 Nov 12;125(45):13654-5. doi: 10.1021/ja036752l.
PMID:14599191
Abstract
Disulfide cross-linked oligonucleotides for connecting two DNA double helixes have been designed, synthesized, and characterized. Employing these cross-linked oligonucleotides, two double helixes can be arranged side by side, and the orientations can be controlled both in parallel and antiparallel ways by addition of a specific complementary DNA strand.
摘要
已设计、合成并表征了用于连接两条DNA双螺旋的二硫键交联寡核苷酸。利用这些交联寡核苷酸，两条双螺旋可以并排排列，并且通过添加特定的互补DNA链，可以以平行和反平行方式控制其方向。
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