来自水生植物篦齿眼子菜的对映-半日花烷二萜类化合物。

ent-Labdane diterpenes from the aquatic plant Potamogeton pectinatus.

作者信息

Waridel Patrice, Wolfender Jean-Luc, Lachavanne Jean-Bernard, Hostettmann Kurt

机构信息

Institut de Pharmacognosie et Phytochimie, Université de Lausanne, CH-1015 Lausanne, Switzerland.

出版信息

Phytochemistry. 2003 Dec;64(7):1309-17. doi: 10.1016/j.phytochem.2003.08.014.

DOI:10.1016/j.phytochem.2003.08.014

PMID:14599530

Abstract

Four new ent-labdane diterpenes were isolated from the freshwater aquatic plant Potamogeton pectinatus, together with two known furano-ent-labdanes. The new compounds were assigned the structures methyl-15,16-epoxy-12(R)-acetoxy- 8(17), 13(16),14-ent-labdatrien-19-oate,15,16-epoxy-12(R)-acetoxy-8(17), 13(16),14-ent-labdatrien-19-oic acid, 8(17),13-ent-labdadien-15 --> 16-lactone-19-oic acid and 16-hydroxy-8(17),13-ent-labdadien-15,16-olid-19-oic acid by spectroscopic means. Some of these labdanes showed a strong algicidal activity against Raphidocelis subcapitata.

摘要

从淡水水生植物篦齿眼子菜中分离出四种新的对映-贝壳杉烷二萜，以及两种已知的呋喃对映-贝壳杉烷。通过光谱手段确定了这些新化合物的结构，分别为甲基-15,16-环氧-12(R)-乙酰氧基-8(17),13(16),14-对映-贝壳杉三烯-19-酯、15,16-环氧-12(R)-乙酰氧基-8(17),13(16),14-对映-贝壳杉三烯-19-酸、8(17),13-对映-贝壳杉二烯-15→16-内酯-19-酸和16-羟基-8(17),13-对映-贝壳杉二烯-15,16-环氧化物-19-酸。其中一些贝壳杉烷对斜生栅藻表现出很强的杀藻活性。