来自杜松子的半日花烷二萜类化合物。

Labdane diterpenes from Juniperus communis L. berries.

作者信息

Martin Anne Marie, Queiroz Emerson Ferreira, Marston Andrew, Hostettmann Kurt

机构信息

Laboratory of Pharmacognosy and Phytochemistry, University of Geneva, Geneva, Switzerland.

出版信息

Phytochem Anal. 2006 Jan-Feb;17(1):32-5. doi: 10.1002/pca.878.

DOI:10.1002/pca.878

PMID:16454474

Abstract

A phytochemical study of the methanol extract of Juniperus communis berries was undertaken. The crude extract was analysed by HPLC-UV and the isolation of the minor compounds was performed by centrifugal partition chromatography. By this means, five diterpenes were isolated, one of which was a new labdane diterpene 15,16-epoxy-12-hydroxy-8(17),13(16),14-labdatrien-19-oic acid. The structures of the isolated compounds were elucidated by spectroscopic methods, including UV, NMR, MS and HR-MS.

摘要

对杜松子甲醇提取物进行了植物化学研究。通过高效液相色谱 - 紫外检测法对粗提取物进行分析，并采用离心分配色谱法分离次要化合物。通过这种方法，分离出了五种二萜类化合物，其中一种是新的半日花烷型二萜15,16 - 环氧 - 12 - 羟基 - 8(17),13(16),14 - 拉布达三烯 - 19 - 酸。通过光谱方法，包括紫外光谱、核磁共振光谱、质谱和高分辨质谱，阐明了分离出的化合物的结构。