Wang Yu-Long, Zhu Yong-Xue, Chen Tong-Zhen, Wang Yu, Sun Guo-Hua, Zhang Ling, Huang Cai-Ping, Wang Zhuo-Ying, Shen Qiang, Li Duan-Shu, Wu Yi, Ji Qing-Hai
Department of Head & Neck Surgery, Cancer Hospital, Fudan University, Shanghai, China.
Acta Otolaryngol. 2012 Aug;132(8):879-86. doi: 10.3109/00016489.2012.662715. Epub 2012 Apr 12.
Chinese patients have a higher rate of lymphoepithelial carcinoma (LEC) and salivary duct carcinoma (SDC). Comprehensive use of diagnostic modalities, neck dissection, and postoperative radiation will improve the treatment results for salivary gland tumors (SGTs).
To study the clinicopathological characteristics of SGTs in a Chinese population.
The records of SGT patients operated in a tertiary cancer hospital of China were retrieved.
From December 1997 to December 2007, 289 malignant and 887 benign SGTs were operated at Cancer Hospital, Shanghai, China. Pleomorphic adenoma and Warthin's tumor were the most common types of SGT. Mucoepidermoid carcinoma (24.6% of malignant cases) and adenoid cystic carcinoma (18.0%) were the most frequent malignant cases, followed by acinic cell carcinoma (12.1%), LEC (9.7%), and SDC (9.3%). The sensitivity and specificity of ultrasound scan, fine needle aspiration biopsy, and frozen section were 58.3 and 88.6%, 87.2 and 96.7%, 86.9 and 99.6%, respectively. Neck dissections and postoperative radiation were carried out for 48.6 and 48.0% of carcinomas, respectively. The percentage of tumors by pathologic TNM stage were 23.7% for stage I, 32.9% for stage II, 17.3% for stage III, and 26.1% for stage IV. The 5-year overall survival rate was 88.0%.
中国患者的淋巴上皮癌（LEC）和涎腺导管癌（SDC）发生率较高。综合运用诊断方法、颈部清扫术和术后放疗将改善涎腺肿瘤（SGT）的治疗效果。
研究中国人群中涎腺肿瘤的临床病理特征。
检索中国一家三级癌症医院接受手术的涎腺肿瘤患者的记录。
1997年12月至2007年12月，中国上海癌症医院对289例恶性和887例良性涎腺肿瘤进行了手术。多形性腺瘤和沃辛瘤是涎腺肿瘤最常见的类型。黏液表皮样癌（占恶性病例的24.6%）和腺样囊性癌（18.0%）是最常见的恶性病例，其次是腺泡细胞癌（12.1%）、淋巴上皮癌（9.7%）和涎腺导管癌（9.3%）。超声检查、细针穿刺活检和冰冻切片的敏感性和特异性分别为58.3%和88.6%、87.2%和96.7%、86.9%和99.6%。分别有48.6%和48.0%的癌症患者进行了颈部清扫术和术后放疗。按病理TNM分期，I期肿瘤占23.7%，II期占32.9%，III期占17.3%，IV期占26.1%。5年总生存率为88.0%。
