香港华人慢性锂盐治疗期间的甲状腺异常：一项对照研究。

Thyroid abnormalities during chronic lithium treatment in Hong Kong Chinese: a controlled study.

作者信息

Lee S, Chow C C, Wing Y K, Shek C C

机构信息

Department of Psychiatry, Chinese University of Hong Kong, Shatin.

出版信息

J Affect Disord. 1992 Nov;26(3):173-8. doi: 10.1016/0165-0327(92)90013-v.

DOI:10.1016/0165-0327(92)90013-v

PMID:1460167

Abstract

Fifty Chinese psychiatric patients on chronic lithium treatment and the same number of sex- and age-matched control outpatients were assessed by a thyroidologist and underwent laboratory investigations. Lithium patients had a higher rate of goitres (50% vs 10%, P < 0.0001) and a higher mean TSH level (P < 0.005) than controls. Thyroid antibodies were detected in 7 older manic-depressive patients as opposed to 1 control, but not in patients with recurrent unipolar mania. Five patients, but no controls, had single or multiple episodes of hyperthyroidism, which was followed in 2 of them by biochemical hypothyroidism. It is suggested that variations in iodine status, dietary goitrogens, immunogenetic makeup and their complex interactions with chronic lithium treatment may contribute to ethnically different patterns of thyroid abnormalities.

摘要

一位甲状腺专家对50名接受慢性锂盐治疗的中国精神科患者以及相同数量的性别和年龄匹配的对照门诊患者进行了评估，并对他们进行了实验室检查。与对照组相比，锂盐治疗患者的甲状腺肿发生率更高（50% 对10%，P < 0.0001），平均促甲状腺激素（TSH）水平也更高（P < 0.005）。在7名老年躁郁症患者中检测到甲状腺抗体，而对照组仅1例检测到，复发性单相躁狂症患者未检测到。5名患者出现了一次或多次甲状腺功能亢进发作，而对照组无此情况，其中2名患者随后出现了生化性甲状腺功能减退。研究表明，碘状态、膳食甲状腺肿原、免疫遗传构成的差异以及它们与慢性锂盐治疗的复杂相互作用，可能导致不同种族甲状腺异常模式的差异。