用3种不同的抗牛病毒性腹泻病毒和牛疱疹病毒-1的商业疫苗对奶牛犊进行接种后体液免疫反应的比较。
Comparison of humoral immune responses in dairy heifers vaccinated with 3 different commercial vaccines against bovine viral diarrhea virus and bovine herpesvirus-1.
作者信息
DesCôteaux Luc, Cécyre Dominique, Elsener Johanne, Beauchamp Guy
机构信息
Départment de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, C.P. 5000, St-Hyacinthe, Quebec J2S 7C6.
出版信息
Can Vet J. 2003 Oct;44(10):816-21.
A randomized clinical trial was conducted to compare the humoral immune response to 3 different commercial vaccines in dairy heifers housed in 3 different dairy farms in Quebec. All heifers were seronegative to type 1 bovine viral diarrhea virus (BVDV) (Singer strain), type 2 BVDV (NVSL 125c strain), and bovine herpesvirus-1 (BHV-1) at the beginning of the trial. In addition, control heifers in group 1 remained seronegative to the 2 viruses till the end of the trial. Significant differences in humoral immune responses occurred among the 3 commercial vaccines at 4 weeks and 6 months following vaccination. The vaccine in group 2 elicited higher mean antibody titers and seroconversion rates to both type 1 and type 2 BVDV than that in groups 3 or 4. Vaccines in groups 2 and 3 induced higher mean antibody titers to BHV-1 than did the vaccine in group 4.
在魁北克的3个不同奶牛场中，对饲养的奶牛小母牛进行了一项随机临床试验，以比较它们对3种不同商业疫苗的体液免疫反应。在试验开始时，所有小母牛对1型牛病毒性腹泻病毒（BVDV）（辛格毒株）、2型BVDV（NVSL 125c毒株）和牛疱疹病毒-1（BHV-1）均呈血清阴性。此外，第1组的对照小母牛在试验结束时对这2种病毒仍保持血清阴性。接种疫苗后4周和6个月时，3种商业疫苗的体液免疫反应存在显著差异。第2组的疫苗对1型和2型BVDV诱导的平均抗体滴度和血清转化率均高于第3组或第4组。第2组和第3组中的疫苗对BHV-1诱导的平均抗体滴度高于第4组中的疫苗。
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