4,4-二取代-2-咪唑啉酮的不对称合成：强效NK1拮抗剂
Asymmetric synthesis of 4,4-disubstituted-2-imidazoli-dinones: potent NK1 antagonists.
作者信息
Reichard Gregory A, Stengone Carmine, Paliwal Sunil, Mergelsberg Ingrid, Majmundar Sapna, Wang Cheng, Tiberi Robert, McPhail Andrew T, Piwinski John J, Shih Neng-Yang
机构信息
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA.
出版信息
Org Lett. 2003 Nov 13;5(23):4249-51. doi: 10.1021/ol030104p.
PMID:14601972
Abstract
[structure: see text] A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.
摘要
[结构：见正文] 描述了一种利用“手性中心自复制”策略高效且实用地合成4,4-二取代-2-咪唑啉酮的方法。
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