健康早产儿胃内pH值的多点测量
Multipoint measurement of intragastric pH in healthy preterm infants.
作者信息
Omari T I, Davidson G P
机构信息
Centre for Paediatric and Adolescent Gastroenterology, Women's and Children's Hospital and Department of Paediatrics, University of Adelaide, Adelaide, South Australia.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2003 Nov;88(6):F517-20. doi: 10.1136/fn.88.6.f517.
BACKGROUND
The diagnostic use of 24 hour oesophageal pH monitoring in infants is controversial because of the impact of feed buffering of gastric acidity.
AIM
To re-evaluate the effect of feeding on gastric pH and reflux using multipoint pH measurements.
SUBJECTS
Fifteen healthy premature infants fed every four hours.
METHODS
Oesophageal pH and intragastric pH at 3, 6, and 9 cm below the lower oesophageal sphincter were simultaneously measured using a four channel pH probe for four hours after bolus feeding. Parameters of pH were compared for the different levels within the stomach. During reflux episodes, the nadir pH was compared with intragastric pH at all levels.
RESULTS
The proximal stomach was more significantly buffered by feeding and slower to re-acidify postprandially than the mid and distal stomach (42.2% of the time at pH < 4 compared with 58.7% and 55.7% respectively). During 27 of 62 gastro-oesophageal reflux episodes, nadir oesophageal pH was lower than the pH of the proximal stomach but always equal to or higher than the pH of the distal stomach.
CONCLUSIONS
These data indicate that previous studies may have overestimated the effect of feeding on gastric acidity and reflux.
背景
由于喂养对胃酸的缓冲作用，24小时食管pH监测在婴儿中的诊断应用存在争议。
目的
使用多点pH测量重新评估喂养对胃pH值和反流的影响。
研究对象
15名每四小时喂养一次的健康早产儿。
方法
在一次推注喂养后，使用四通道pH探头同时测量食管下括约肌下方3厘米、6厘米和9厘米处的食管pH值和胃内pH值，持续4小时。比较胃内不同水平的pH参数。在反流发作期间，比较最低点pH值与所有水平的胃内pH值。
结果
近端胃受喂养的缓冲作用更显著，餐后再酸化的速度比胃中部和远端更慢（pH<4的时间分别为42.2%、58.7%和55.7%）。在62次胃食管反流发作中的27次，食管最低点pH值低于近端胃的pH值，但始终等于或高于远端胃的pH值。
结论
这些数据表明，先前的研究可能高估了喂养对胃酸度和反流的影响。
Zotero 插件