来自福州薯蓣（R. Kunth）根茎的新呋甾烷醇糖苷

New furostanol glycosides from the rhizomes of Dioscorea futschauensis R. Kunth.

作者信息

Liu Hong-Wei, Wang San-Long, Cai Bin, Qu Ge-Xia, Yang Xu-Juan, Kobayashi Hisayoshi, Yao Xin-Sheng

机构信息

Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Wenhua-Road 103, Shenyang 110016, China.

出版信息

J Asian Nat Prod Res. 2003 Dec;5(4):241-7. doi: 10.1080/1028602031000105849.

DOI:10.1080/1028602031000105849

PMID:14604232

Abstract

Two new furostanol glycosides, 26-O-beta-D-glucopyranosyl-3beta,26-dihydroxy-23(S)-methoxyl-25(R)-furosta-5,20(22)-dien-3-O-alpha-L-rhamnopyranosyl(1 --> 2)-[beta-D-glucopyranosyl(1 --> 3)]-beta-D-glucopyranoside (dioscoreside E, 1) and 26-O-beta-D-glucopyranosyl-3beta,26-dihydroxy-25(R)-furosta-5,20(22)-dien-3-O-alpha-Lrhamnopyranosyl(1 --> 2)-[beta-D-glucopyranosyl (1 --> 3)]-beta-D-glucopyranoside (prtotogracillin, 2), together with 11 known furostanol glycosides were isolated from the rhizomes of Dioscorea futshauensis R. Kunth. Their structures were elucidated on the basis of spectroscopic analysis (NMR and FABMS). Their anti-fungal activity against the plant pathogenic fungus Pyricularia oryzae and cytotoxic activity on K562 cancer cell line were evaluated in vitro.

摘要

从福州薯蓣（R. Kunth）的根茎中分离得到两种新的呋甾烷醇糖苷，即26 - O - β - D - 吡喃葡萄糖基 - 3β,26 - 二羟基 - 23(S) - 甲氧基 - 25(R) - 呋甾 - 5,20(22) - 二烯 - 3 - O - α - L - 鼠李吡喃糖基(1→2) - [β - D - 吡喃葡萄糖基(1→3)] - β - D - 吡喃葡萄糖苷（薯蓣皂苷E，1）和26 - O - β - D - 吡喃葡萄糖基 - 3β,26 - 二羟基 - 25(R) - 呋甾 - 5,20(22) - 二烯 - 3 - O - α - L - 鼠李吡喃糖基(1→2) - [β - D - 吡喃葡萄糖基(1→3)] - β - D - 吡喃葡萄糖苷（原托格拉西林，2），以及11种已知的呋甾烷醇糖苷。通过光谱分析（核磁共振和快原子轰击质谱）确定了它们的结构。体外评估了它们对植物病原真菌稻瘟病菌的抗真菌活性以及对K562癌细胞系的细胞毒性活性。