Sautour M, Mitaine-Offer A-C, Miyamoto T, Dongmo A, Lacaille-Dubois M-A
Laboratoire de Pharmacognosie, Unité UMIB, EA 3660, Faculté de Pharmacie, Université de Bourgogne, 21079 Dijon, France.
Planta Med. 2004 Jan;70(1):90-2. doi: 10.1055/s-2004-815467.
From the rhizomes of Dioscorea cayenensis Lam.-Holl (Dioscoreaceae), the new 26- O- beta- D-glucopyranosyl-22-methoxy-3 beta,26-dihydroxy-25( R)-furost-5-en-3- O- alpha- L-rhamnopyranosyl-(1-->4)- alpha- L-rhamnopyranosyl-(1-->4)-[ alpha- L-rhamnopyranosyl-(1-->2)]- beta- D-glucopyranoside ( 1) was isolated together with the known dioscin ( 2) and diosgenin 3- O- alpha- L-rhamnopyranosyl-(1-->4)- alpha- L-rhamnopyranosyl-(1-->4)-[ alpha- L-rhamnopyranosyl-(1-->2)]- beta- D-glucopyranoside ( 3). Their structures were established on the basis of spectral data. Compound 2 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 12.5, 12.5 and 25 micro g/mL, respectively) whereas 3 showed weak activity and 1 was inactive.
从黄独（薯蓣科）的根茎中，分离得到新的26 - O - β - D - 吡喃葡萄糖基 - 22 - 甲氧基 - 3β,26 - 二羟基 - 25(R) - 呋甾 - 5 - 烯 - 3 - O - α - L - 鼠李吡喃糖基 - (1→4) - α - L - 鼠李吡喃糖基 - (1→4) - [α - L - 鼠李吡喃糖基 - (1→2)] - β - D - 吡喃葡萄糖苷（1），以及已知的薯蓣皂苷（2）和薯蓣皂苷元3 - O - α - L - 鼠李吡喃糖基 - (1→4) - α - L - 鼠李吡喃糖基 - (1→4) - [α - L - 鼠李吡喃糖基 - (1→2)] - β - D - 吡喃葡萄糖苷（3）。它们的结构通过光谱数据得以确定。化合物2对人类致病酵母白色念珠菌、光滑念珠菌和热带念珠菌表现出抗真菌活性（最低抑菌浓度分别为12.5、12.5和25 μg/mL），而3表现出较弱的活性，1则无活性。
