Kadoya F, Hayashi F, Senda T, Yoshimura Y, Imon H, Arai T
Department of Anesthesiology, Ehime University Medical School.
Masui. 1992 Nov;41(11):1700-6.
We examined the effects of a xanthine derivative, propentofylline, on recovery of brain function following TCI in 23 adult mongrel dogs. TCI was produced by clamping ascending aorta with aortoatrial bypass formation. The dogs were divided into 3 groups: preischemic administration (0.3 mg.kg-1.min-1, 30 min), post-ischemic administration (0.5 mg.kg-1.min-1, 6h) and control. The progress of recovery of EEG, respiration, reflexes, motor functions, arousal state and behavior were observed for 7 days after TCI and the latter 5 functions were analysed using neurologic deficit score (NDS). Propentofylline shortened the time necessary for reappearance of EEG after the starting of recirculation but could not improve the NDS.
我们研究了黄嘌呤衍生物丙戊茶碱对23只成年杂种犬在进行体外循环缺血（TCI）后脑功能恢复的影响。TCI通过在建立主动脉 - 心房旁路的情况下夹闭升主动脉来产生。这些犬被分为3组：缺血前给药组（0.3毫克·千克⁻¹·分钟⁻¹，30分钟）、缺血后给药组（0.5毫克·千克⁻¹·分钟⁻¹，6小时）和对照组。在TCI后观察脑电图、呼吸、反射、运动功能、觉醒状态和行为恢复的进程达7天，并使用神经功能缺损评分（NDS）对后5项功能进行分析。丙戊茶碱缩短了再灌注开始后脑电图再次出现所需的时间，但未能改善NDS。
