Fujimoto S, Mizoi K, Yoshimoto T, Suzuki J
No To Shinkei. 1983 Mar;35(3):305-9.
Using the "Canine model of complete ischemic brain regulated with a perfusion method", the effects of vitamin E which acts as an antioxidant on cerebral ischemia were investigated. After pretreatment with vitamin E by oral or intravenous administration, cerebral blood flow was reduced to 1/10 the normal state and one hour later, return to a normal state allowed. Subsequent changes in electrical activity were observed and the effects of the vitamin E were evaluated. In the control group, no recovery of electrical activity was seen. While in the group of vitamin E administration, the survival time was not prolonged but the recovery time was shortened statistically in the dogs given 30 mg/kg of vitamin E intravenously. Furthermore, in the group treated with vitamin E, distinct recovery of EEG potentials at three hours after recirculation was apparent. These effects were more favorable in the case of intravenous administration than in the case of oral administration. These experimental results indicated that administration of vitamin E is effective in protecting the brain from cerebral ischemia.
采用“通过灌注法调控的全脑缺血犬模型”，研究了作为抗氧化剂的维生素E对脑缺血的影响。通过口服或静脉给予维生素E进行预处理后，将脑血流量降低至正常状态的1/10，1小时后，使其恢复至正常状态。随后观察电活动的变化并评估维生素E的作用。在对照组中，未见电活动恢复。而在给予维生素E的组中，静脉注射30mg/kg维生素E的犬的存活时间虽未延长，但恢复时间在统计学上缩短。此外，在接受维生素E治疗的组中，再灌注3小时后脑电图电位明显恢复。静脉给药的效果比口服给药更显著。这些实验结果表明，给予维生素E可有效保护大脑免受脑缺血损伤。
