Oba M, Mizoi K, Fujimoto S, Yoshimoto T, Suzuki J
No Shinkei Geka. 1985 Oct;13(10):1059-65.
We have previously demonstrated that the preischemic administration of perfluorochemicals (PFC) in combination with 20% mannitol, vitamin E and dexamethasone is effective in protecting the brain from cerebral ischemia. This experimental study was designed to evaluate the effect and limitation of the post-ischemic administration of those 4 agents on cerebral ischemia. We used "Canine model of complete ischemic brain regulated with a perfusion method." Using this model we were able to control the amount of blood flow to the left cerebral hemisphere by using an infusion pump. Infusion blood volume was reduced to 30%, 40% or 50% of the normal state, then the combined treatment was started 1,2,3,4,5 or 6 hours after the onset of ischemia in each ischemic group. By monitoring the EEG for 8 hours of ischemic period, we were able to evaluate the effect of the drugs on cerebral ischemia. In untreated groups, electrical activity deteriorated gradually. In the 30% ischemia group, the EEG became isoelectric within 1 hour following ischemia. In half of the 40% ischemia group, the EEG became isoelectric but in the other half low voltage slow wave were seen to last for 6-8 hours. In the 50% group, the EEG deteriorated gradually but did not disappear within 8 hours. The effectiveness of the treatment was judged by the degree of the recovery of electrical activity. The effectiveness of the treatment appeared to depend on the severity and the duration of ischemia.(ABSTRACT TRUNCATED AT 250 WORDS)
我们之前已经证明，缺血前给予全氟化合物（PFC）联合20%甘露醇、维生素E和地塞米松可有效保护大脑免受脑缺血损伤。本实验研究旨在评估这4种药物缺血后给药对脑缺血的作用及局限性。我们使用“通过灌注方法调节的完全缺血性脑犬模型”。利用该模型，我们能够通过输液泵控制左脑半球的血流量。将输液血量减少至正常状态的30%、40%或50%，然后在每个缺血组缺血开始后1、2、3、4、5或6小时开始联合治疗。通过在缺血期监测8小时脑电图，我们能够评估药物对脑缺血的作用。在未治疗组中，电活动逐渐恶化。在30%缺血组中，缺血后1小时内脑电图变为等电位。在40%缺血组的一半中，脑电图变为等电位，但在另一半中可见低电压慢波持续6 - 8小时。在50%组中，脑电图逐渐恶化，但在8小时内未消失。治疗效果通过电活动恢复程度来判断。治疗效果似乎取决于缺血的严重程度和持续时间。（摘要截选至250字）
