用于药物递送应用的多孔中空二氧化硅纳米粒子的制备与表征
Preparation and characterization of porous hollow silica nanoparticles for drug delivery application.
作者信息
Chen Jian-Feng, Ding Hao-Min, Wang Jie-Xin, Shao Lei
机构信息
College of Chemical Engineering, Research Center of the Ministry of Education for High Gravity Engineering & Technology, Beijing University of Chemical Technology, No 15 Bei San Huan Dong Road, Beijing 100029, China.
出版信息
Biomaterials. 2004 Feb;25(4):723-7. doi: 10.1016/s0142-9612(03)00566-0.
Porous hollow silica nanoparticles (PHSNP) with a diameter of 60-70 nm and wall thickness of approximately 10nm were synthesized by using CaCO(3) nano-particles as the inorganic template. The characterization of PHSNP by TEM and BET indicated that PHSNP were uniform spherical particles with good dispersion, and had a specific surface area of 867 m(2)/g. The as-synthesized PHSNP were subsequently employed as drug carrier to investigate in vitro release behavior of cefradine in simulated body fluid. UV-spectrometry and TG analyses were performed to determine the amount of cefradine entrapped in the carrier. The BJH pore size distribution of PHSNP before and after entrapping cefradine was examined. Cefradine release profile from PHSNP followed a three-stage pattern and exhibited a delayed release effect.
以碳酸钙纳米颗粒为无机模板，合成了直径为60 - 70nm、壁厚约为10nm的多孔中空二氧化硅纳米颗粒（PHSNP）。通过透射电子显微镜（TEM）和比表面积分析仪（BET）对PHSNP进行表征，结果表明PHSNP为均匀的球形颗粒，分散性良好，比表面积为867 m²/g。随后将合成的PHSNP用作药物载体，研究头孢拉定在模拟体液中的体外释放行为。采用紫外光谱法和热重分析法测定载体中包封的头孢拉定含量。考察了包封头孢拉定前后PHSNP的BJH孔径分布。头孢拉定从PHSNP的释放曲线呈三阶段模式，并表现出缓释效果。
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