Au W Y, Ma S Y, Cheng V C C, Ooi C G C, Lie A K W
Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Br J Dermatol. 2003 Oct;149(4):862-5. doi: 10.1046/j.1365-2133.2003.05656.x.
Reactivation of varicella-zoster virus (VZV) is one of the commonest complications after stem cell transplantation, and often presents with atypical manifestations. We describe two unusual cases of occult disseminated zoster in allogeneic stem cell transplant recipients, presenting as severe abdominal pain and syndrome of inappropriate antidiuretic hormone secretion/hyponatraemia, and accompanied by leukaemia relapse. There was complete clinical recovery with high-dose aciclovir and intravenous immunoglobulin. Prompt treatment of leukaemia relapse also resulted in complete remission. A possible immunological link between concurrent breakdown of immune control of VZV and leukaemia is discussed.
水痘带状疱疹病毒（VZV）再激活是干细胞移植后最常见的并发症之一，且常表现为非典型症状。我们描述了两例异基因干细胞移植受者隐匿性播散性带状疱疹的罕见病例，表现为严重腹痛和抗利尿激素分泌异常综合征/低钠血症，并伴有白血病复发。高剂量阿昔洛韦和静脉注射免疫球蛋白治疗后临床完全康复。白血病复发的及时治疗也导致完全缓解。本文讨论了VZV免疫控制同时崩溃与白血病之间可能存在的免疫联系。
