造血干细胞移植后出现皮肤表现之前，严重腹痛、抗利尿激素分泌不当和播散性水痘-带状疱疹病毒感染三联征：PCR在早期识别和治疗中的应用

Triad of severe abdominal pain, inappropriate antidiuretic hormone secretion, and disseminated varicella-zoster virus infection preceding cutaneous manifestations after hematopoietic stem cell transplantation: utility of PCR for early recognition and therapy.

作者信息

Rau Rachel, Fitzhugh Courtney D, Baird Kristin, Cortez Karroll J, Li Li, Fischer Steven H, Cowen Edward W, Balow James E, Walsh Thomas J, Cohen Jeffrey I, Wayne Alan S

机构信息

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1104, USA.

出版信息

Pediatr Infect Dis J. 2008 Mar;27(3):265-8. doi: 10.1097/INF.0b013e31815cb239.

DOI:10.1097/INF.0b013e31815cb239

PMID:18277922

Abstract

A hematopoietic stem cell transplant recipient developed abdominal pain, pneumatosis intestinalis, hepatitis, pancreatitis, and inappropriate antidiuretic hormone secretion. Blood for varicella-zoster virus (VZV) DNA polymerase chain reaction was positive. She was treated with acyclovir and subsequently developed VZV antigen-positive zoster. Detection of VZV DNA in blood may be useful for early diagnosis in immunocompromised hosts who present with zoster without skin lesions.

摘要

一名造血干细胞移植受者出现腹痛、肠壁积气、肝炎、胰腺炎及抗利尿激素分泌异常。水痘-带状疱疹病毒（VZV）DNA聚合酶链反应检测血液呈阳性。她接受了阿昔洛韦治疗，随后出现VZV抗原阳性的带状疱疹。对于出现无皮肤损害的带状疱疹的免疫功能低下宿主，检测血液中的VZV DNA可能有助于早期诊断。