Kossard S
Skin & Cancer Foundation Australia, Darlinghurst, NSW, Australia.
Clin Exp Dermatol. 2003 Nov;28 Suppl 1:13-5. doi: 10.1046/j.1365-2230.28.s1.5.x.
Bowen's disease (BD; squamous cell carcinoma in situ) is a common, persistent condition that can be related to chronic sun damage, and consequently, is usually located around the head and neck area and lower limbs. Bowen's disease can be treated with a variety of methods, including surgery or laser therapy, but large lesions tend to scar postexcision and hence are difficult to treat surgically. Here we present the case of a 75-year-old woman with a 20-year history of facial BD unabated by treatment with a variety of topical agents and cryotherapy. Application of imiquimod 5% cream on alternate nights for 6 weeks resulted in total clearance with no recurrence observed after 8 months.
鲍温病（BD；原位鳞状细胞癌）是一种常见的持续性疾病，可能与慢性阳光损伤有关，因此通常位于头颈部和下肢。鲍温病可以通过多种方法治疗，包括手术或激光治疗，但大的病变切除后往往会留下疤痕，因此手术治疗困难。在此，我们报告一例75岁女性患者，面部鲍温病病史20年，使用多种外用药物和冷冻疗法治疗均未缓解。每晚交替使用5%咪喹莫特乳膏，持续6周，病变完全清除，8个月后未见复发。
