Micali G, Lacarrubba F, Nasca M R, De Pasquale R
Dermatology Clinic, University of Catania, Catania, Italy.
Clin Exp Dermatol. 2003 Nov;28 Suppl 1:19-23. doi: 10.1046/j.1365-2230.28.s1.7.x.
Gorlin's syndrome (naevoid basal cell carcinoma) is an autosomal dominant tumour-predisposition syndrome. It typically consists of multiple basal cell carcinomas (BCCs) of the skin, odontogenic keratocysts of the jaw, various skeletal abnormalities and lamellar falx calcifications. Four patients with multiple facial and trunk BCCs (superficial and nodular) consistent with Gorlin's syndrome are reported. Imiquimod 5% cream was topically applied to the lesions 3-5 times a week for 8-14 weeks. Two of the patients suffered mild to severe erythema and developed superficial erosions but did not discontinue treatment. Imiquimod 5% cream successfully treated 13 out of 17 BCCs in these patients with Gorlin's syndrome, with no patient suffering a relapse at the follow-up visit.
戈林综合征（痣样基底细胞癌综合征）是一种常染色体显性肿瘤易感综合征。它通常表现为皮肤多发性基底细胞癌（BCC）、颌骨牙源性角化囊肿、各种骨骼异常以及板层状大脑镰钙化。本文报告了4例符合戈林综合征的面部和躯干多发性BCC（浅表性和结节性）患者。每周3 - 5次在皮损处外用5%咪喹莫特乳膏，持续8 - 14周。2例患者出现轻至重度红斑并形成浅表糜烂，但未中断治疗。5%咪喹莫特乳膏成功治疗了这些戈林综合征患者17处BCC中的13处，随访时无患者复发。
