Prescott L, Durkin M, Furchtgott E, Powell D A
Neuroscience Laboratory, Wm. Jennings Bryan Dorn VA Medical Center, Columbia, South Carolina.
Psychophysiology. 1992 Nov;29(6):646-56. doi: 10.1111/j.1469-8986.1992.tb02040.x.
Pavlovian heart rate and eyeblink conditioning were simultaneously assessed in human subjects. Tone durations of 0.6, 1.1, and 2.1 s were employed in separate groups of subjects as the conditioned stimulus. A 100-ms corneal airpuff, which served as the unconditioned stimulus, overlapped the last 100 ms of the tone in each group, thus producing interstimulus intervals of 0.5, 1.0, and 2.0 s. Other groups of pseudoconditioning subjects received explicitly unpaired tone and airpuff presentations of identical durations but in a pseudorandom sequence so that they never occurred together. The best eyeblink conditioning was observed in the group with the .5-s interstimulus interval, although the 1.0-s group also demonstrated some evidence of eyeblink conditioning. The group with the 2.0-s interstimulus interval showed a lower overall rate of conditioned response occurrence and the highest rate of pseudoconditioned responding. The conditioned heart rate response in all three conditioning groups consisted of cardiac decelerations, but tone-evoked cardiac accelerations were observed in the pseudoconditioning groups. The magnitude of the cardiac deceleration was comparable in all three conditioning groups.
在人类受试者中同时评估了巴甫洛夫式心率和眨眼条件反射。在不同组的受试者中分别采用0.6秒、1.1秒和2.1秒的音调持续时间作为条件刺激。一个100毫秒的角膜吹气作为非条件刺激，在每组中与音调的最后100毫秒重叠，从而产生0.5秒、1.0秒和2.0秒的刺激间隔。其他伪条件反射组的受试者接受明确不配对的、持续时间相同的音调和吹气呈现，但顺序是伪随机的，这样它们就不会同时出现。在刺激间隔为0.5秒的组中观察到最佳的眨眼条件反射，尽管刺激间隔为1.0秒的组也显示出一些眨眼条件反射的证据。刺激间隔为2.0秒的组显示出较低的条件反应总体发生率和最高的伪条件反应率。所有三个条件反射组的条件心率反应均包括心脏减速，但在伪条件反射组中观察到音调诱发的心脏加速。所有三个条件反射组的心脏减速幅度相当。
