Gabrieli J D, McGlinchey-Berroth R, Carrillo M C, Gluck M A, Cermak L S, Disterhoft J F
Memory Disorders Research Center, Boston University School of Medicine, USA.
Behav Neurosci. 1995 Oct;109(5):819-27. doi: 10.1037//0735-7044.109.5.819.
The status of classical conditioning in human amnesia was examined by comparing conditioning of the eyeblink response (the unconditional response) to a tone conditioned stimulus (CS) paired with an airpuff unconditioned stimulus (US) in the delay paradigm between 7 amnesic and 7 age- and education-matched normal control participants. Amnesic patients exhibited normal baseline performance in pseudoconditioning and normal acquisition and extinction of conditioned responses in terms of the number, latency, and magnitude of eyeblinks. These results indicate that in humans, as in rabbits, brain structures critical for declarative memory are not essential for the acquisition of elementary CS-US associations.
通过比较7名失忆症患者和7名年龄及教育程度匹配的正常对照参与者在延迟范式中，对与吹气非条件刺激（US）配对的音调条件刺激（CS）的眨眼反应（非条件反应）的条件反射情况，研究了经典条件反射在人类失忆症中的状态。失忆症患者在伪条件反射中表现出正常的基线表现，并且在眨眼的数量、潜伏期和幅度方面，条件反应的习得和消退也正常。这些结果表明，在人类中，如同在兔子中一样，对陈述性记忆至关重要的脑结构对于基本的CS-US关联的习得并非必不可少。
