The long-term effect of diode laser cyclodestruction on intraocular pressure.

We retrospectively reviewed the first 24 patients (26 eyes) who underwent ab externo diode laser cyclodestruction for refractory glaucoma and who had a follow-up of at least 10 months. We compared the intraocular pressure (IOP) and the number of antiglaucomatous medications used pre- and postoperatively. The mean follow-up period was 28 months (range 10 to 50 months). The mean IOP before and after treatment was respectively 30 +/- 12 mmHg and 22 +/- 12 mmHg (p < 0.05), a mean reduction of 29%. The average number of treatment sessions was 1.5 (range 1 to 5). An IOP < or = 21 mmHg was obtained in 65% of the cases; an IOP < or = 17 mmHg was achieved in 46% of the cases. The mean number of anti-glaucomatous medications used pre- and postoperatively was respectively 2.3 and 1.7 (p < 0.05). Only mild postoperative uveitis was observed; no eye developed phthisis bulbi. The study suggests that diode laser cyclodestruction is a safe procedure that can reduce the IOP in the long term in patients with refractory glaucoma.