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1
Helicobacter pylori CheZ(HP) and ChePep form a novel chemotaxis-regulatory complex distinct from the core chemotaxis signaling proteins and the flagellar motor.幽门螺杆菌CheZ（HP）和ChePep形成一种新型趋化性调节复合物，不同于核心趋化性信号蛋白和鞭毛马达。
Mol Microbiol. 2015 Sep;97(6):1063-78. doi: 10.1111/mmi.13086. Epub 2015 Jul 4.
2
Immune evasion strategies used by Helicobacter pylori.幽门螺杆菌采用的免疫逃避策略。
World J Gastroenterol. 2014 Sep 28;20(36):12753-66. doi: 10.3748/wjg.v20.i36.12753.
3
Outer membrane inflammatory protein A, a new virulence factor involved in the pathogenesis of Helicobacter pylori.外膜炎症蛋白A，一种参与幽门螺杆菌致病机制的新毒力因子。
Mol Biol Rep. 2014 Dec;41(12):7807-14. doi: 10.1007/s11033-014-3673-9. Epub 2014 Aug 6.
4
Motility and chemotaxis mediate the preferential colonization of gastric injury sites by Helicobacter pylori.运动性和趋化性介导幽门螺杆菌对胃损伤部位的优先定植。
PLoS Pathog. 2014 Jul 17;10(7):e1004275. doi: 10.1371/journal.ppat.1004275. eCollection 2014 Jul.
5
Factors that mediate colonization of the human stomach by Helicobacter pylori.介导幽门螺杆菌在人胃部定植的因素。
World J Gastroenterol. 2014 May 21;20(19):5610-24. doi: 10.3748/wjg.v20.i19.5610.
6
Virulence Factors of Helicobacter pylori: A Review.幽门螺杆菌的毒力因子：综述
Clin Med Insights Gastroenterol. 2014 Mar 27;7:9-17. doi: 10.4137/CGast.S13760. eCollection 2014.
7
The role of the bacterial flagellum in adhesion and virulence.细菌鞭毛在黏附和毒力中的作用。
Biology (Basel). 2013 Oct 25;2(4):1242-67. doi: 10.3390/biology2041242.
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Interactions of bacterial flagellar chaperone-substrate complexes with FlhA contribute to co-ordinating assembly of the flagellar filament.细菌鞭毛接头蛋白-底物复合物与 FlhA 的相互作用有助于协调鞭毛丝的组装。
Mol Microbiol. 2013 Dec;90(6):1249-61. doi: 10.1111/mmi.12430. Epub 2013 Oct 30.
9
The Influence of Mucus Microstructure and Rheology in Helicobacter pylori Infection.黏液微观结构和流变学在幽门螺杆菌感染中的影响
Front Immunol. 2013 Oct 10;4:310. doi: 10.3389/fimmu.2013.00310.
10
Helicobacter pylori FliD protein is a highly sensitive and specific marker for serologic diagnosis of H. pylori infection.幽门螺杆菌 FliD 蛋白是血清学诊断幽门螺杆菌感染的高度敏感和特异标志物。
Int J Med Microbiol. 2013 Dec;303(8):618-23. doi: 10.1016/j.ijmm.2013.08.005. Epub 2013 Sep 3.

鞭毛在幽门螺杆菌致病机制中的作用。

Role of Flagella in the Pathogenesis of Helicobacter pylori.

作者信息

Gu Haiying

机构信息

Medical School, Ningbo University, Ningbo, 315211, China.

出版信息

Curr Microbiol. 2017 Jul;74(7):863-869. doi: 10.1007/s00284-017-1256-4. Epub 2017 Apr 26.

DOI:10.1007/s00284-017-1256-4
PMID:28444418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5447363/
Abstract

This review aimed to investigate the role of Helicobacter pylori flagella on the pathogenicity of this bacterium in humans. Helicobacter pylori is a flagellated pathogen that colonizes the human gastroduodenal mucosa and produces inflammation, and is responsible for gastrointestinal disease. Its pathogenesis is attributed to colonization and virulence factors. The primary function of H. pylori flagella is to provide motility. We believe that H. pylori flagella play an important role in the colonization of the gastrointestinal mucosa. Therefore, we reviewed previous studies on flagellar morphology and motility in order to explore the relationship between H. pylori flagella and pathogenicity. Further investigation is required to confirm the association between flagella and pathogenicity in H. pylori.

摘要

本综述旨在研究幽门螺杆菌鞭毛在该细菌对人类致病性中的作用。幽门螺杆菌是一种有鞭毛的病原体，可定殖于人类胃十二指肠黏膜并引发炎症，是胃肠道疾病的病因。其发病机制归因于定殖和毒力因子。幽门螺杆菌鞭毛的主要功能是提供运动性。我们认为幽门螺杆菌鞭毛在胃肠道黏膜定殖中发挥重要作用。因此，我们回顾了以往关于鞭毛形态和运动性的研究，以探讨幽门螺杆菌鞭毛与致病性之间的关系。需要进一步研究来证实幽门螺杆菌鞭毛与致病性之间的关联。