Hilgers K, Stoll T, Skakun Y, Coenen H H, Qaim S M
Institut für Nuklearchemie, Forschungszentrum Jülich GmbH, D-52425 Jülich, Germany.
Appl Radiat Isot. 2003 Nov-Dec;59(5-6):343-51. doi: 10.1016/s0969-8043(03)00199-4.
The radionuclides 64Cu (T1/2=12.7h) and 67Cu (T1/2=61.9h) are useful in internal therapy. In connection with production of 64Cu, excitation functions of the reactions natZn(d,x)64Cu, 66Zn(d,alpha)64Cu and 68Zn(p,alphan)64Cu were measured radiochemically using the stacked-foil technique. From the measured data, the thick target yields of 64Cu were calculated and compared with experimental data available in the literature. The three investigated processes are discussed in comparison to the commonly used 64Ni(p,n)64Cu reaction for the production of 64Cu. As regards 67Cu production, the technical feasibility of the 70Zn(p,alpha)67Cu process was investigated. An electroplated isotopically enriched 70Zn target was developed which can withstand slanting beams of 20MeV protons of currents up to 20 microA. Methods for chemical separation of 67Cu and efficient recovery of the enriched target material were worked out. The method is suitable only for small-scale production of 67Cu.
放射性核素64Cu（半衰期T1/2 = 12.7小时）和67Cu（半衰期T1/2 = 61.9小时）可用于内照射治疗。在64Cu的生产方面，采用叠层箔技术通过放射化学方法测量了天然锌（natZn）（d，x）64Cu、66Zn（d，α）64Cu和68Zn（p，αn）64Cu反应的激发函数。根据测量数据计算了64Cu的厚靶产额，并与文献中的实验数据进行了比较。将所研究的三个过程与常用的用于生产64Cu的64Ni（p，n）64Cu反应进行了比较讨论。关于67Cu的生产，研究了70Zn（p，α）67Cu过程的技术可行性。研制了一种电镀的同位素富集70Zn靶，它能够承受高达20微安的20兆电子伏质子斜入射束流。制定了67Cu的化学分离方法以及富集靶材料的有效回收方法。该方法仅适用于67Cu的小规模生产。
