Brühlmann Santiago Andrés, Walther Martin, Kreller Martin, Reissig Falco, Pietzsch Hans-Jürgen, Kniess Torsten, Kopka Klaus
Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, Germany.
School of Science, Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany.
Pharmaceuticals (Basel). 2023 Feb 17;16(2):314. doi: 10.3390/ph16020314.
Theranostic matched pairs of radionuclides have aroused interest during the last couple of years, and in that sense, copper is one element that has a lot to offer, and although Cu and Cu are slowly being established as diagnostic radionuclides for PET, the availability of the therapeutic counterpart Cu plays a key role for further radiopharmaceutical development in the future. Until now, the Cu shortage has not been solved; however, different production routes are being explored. This project aims at the production of no-carrier-added Cu with high radionuclidic purity with a medical 30MeV compact cyclotron via the Zn(p,α)Cu reaction. With this purpose, proton irradiation of electrodeposited Zn targets was performed followed by two-step radiochemical separation based on solid-phase extraction. Activities of up to 600MBq Cu at end of bombardment, with radionuclidic purities over 99.5% and apparent molar activities of up to 80MBq/nmol, were quantified.
放射性核素的诊疗配对在过去几年引起了人们的关注，从这个意义上说，铜是一种极具潜力的元素。尽管铜-62和铜-64正逐渐成为用于正电子发射断层扫描（PET）的诊断性放射性核素，但治疗用的对应物铜-67对于未来放射性药物的进一步发展起着关键作用。到目前为止，铜-67的短缺问题尚未解决；然而，人们正在探索不同的生产路线。该项目旨在通过锌（p，α）铜反应，利用医用30MeV紧凑型回旋加速器生产无载体添加且放射性核素纯度高的铜-67。为此，对电沉积的锌靶进行质子辐照，然后基于固相萃取进行两步放射化学分离。在轰击结束时，定量得到了活度高达600MBq的铜-67，其放射性核素纯度超过99.5%，表观摩尔活度高达80MBq/nmol。
