Kręcisz Paweł, Stefańska Katarzyna, Studziński Jakub, Pitucha Monika, Czylkowska Agnieszka, Szymański Paweł
Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland.
Independent Radiopharmacy Unit, Faculty of Pharmacy, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.
J Med Chem. 2025 Feb 13;68(3):2356-2376. doi: 10.1021/acs.jmedchem.4c02885. Epub 2025 Feb 2.
Of the 32 known copper isotopes, some have interesting properties for nuclear medicine, for example the short-lived Cu, Cu, Cu, the moderate long-lived Cu and the long-lived Cu. Due to their emission properties, copper isotopes are suitable for both imaging diagnostics (Cu, Cu, Cu, Cu) and targeted radiotherapy (Cu and Cu). As their chemical properties are virtually identical, a single radiopharmaceutical structure can be labeled with different isotopes, depending on the clinical application. This, combined with the ability to combine radioisotopes with different nuclear properties with the same ligand, makes them extremely versatile. The purpose of this review is to introduce the world of copper radiopharmaceuticals and to summarize recent advances in methods for producing copper radioisotopes and the preclinical research of radiopharmaceuticals labeled with copper radioisotopes.
在已知的32种铜同位素中，有些对核医学具有有趣的特性，例如短寿命的铜-60、铜-61、铜-62，中等长寿命的铜-64以及长寿命的铜-67。由于它们的发射特性，铜同位素适用于成像诊断（铜-60、铜-61、铜-62、铜-64）和靶向放疗（铜-64和铜-67）。由于它们的化学性质几乎相同，单一的放射性药物结构可以根据临床应用用不同的同位素进行标记。这一点，再加上能够将具有不同核性质的放射性同位素与相同的配体相结合的能力，使得它们具有极强的通用性。本综述的目的是介绍铜放射性药物的领域，并总结生产铜放射性同位素的方法以及用铜放射性同位素标记的放射性药物的临床前研究的最新进展。
