鼠巨细胞病毒感染的发病机制。

Pathogenesis of murine cytomegalovirus infection.

作者信息

Krmpotic Astrid, Bubic Ivan, Polic Bojan, Lucin Pero, Jonjic Stipan

机构信息

Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia.

出版信息

Microbes Infect. 2003 Nov;5(13):1263-77. doi: 10.1016/j.micinf.2003.09.007.

DOI:10.1016/j.micinf.2003.09.007

PMID:14623023

Abstract

Infection of mice with murine cytomegalovirus (MCMV) is an established model for studying human cytomegalovirus (HCMV) infection. Similarly to HCMV infection, pathological changes and disease manifestations during MCMV infection are mainly dependent on the immune status of the mouse host. This review focuses mainly on the pathogenesis of MCMV infection in immunocompetent and immunodeficient and/or immature mice and discusses the principles of immunosurveillance of infection and the mechanisms by which this virus evades immune control.

摘要

用鼠巨细胞病毒（MCMV）感染小鼠是研究人类巨细胞病毒（HCMV）感染的一个成熟模型。与HCMV感染相似，MCMV感染期间的病理变化和疾病表现主要取决于小鼠宿主的免疫状态。本综述主要关注免疫健全、免疫缺陷和/或未成熟小鼠中MCMV感染的发病机制，并讨论感染免疫监视的原理以及该病毒逃避免疫控制的机制。