Ruszczak Zbigniew
INNOCOLL GmbH, Saal, Germany.
Adv Drug Deliv Rev. 2003 Nov 28;55(12):1595-611. doi: 10.1016/j.addr.2003.08.003.
Dermal substitution and wound healing are areas of medicine in which there have been many recent advances, but neither the commercially available products nor the products currently described in experimental studies are able to fully substitute for natural living skin. There is an overall consensus that to heal wounds, the substitution of connective tissue matrix, the main component of each wound, is necessary. Both artificial and natural polymers have been used to reconstitute dermis. Nowadays, collagen has been discovered again. Collagen is a natural substrate for cellular attachment, growth and differentiation, and promotes cellular proliferation and differentiation. Once dermis reconstruction is done, the covering of the wound surface with both in vitro expanded epidermis and autologous split-skin transplants is significantly easier and has an improved chance of success. Nowadays, many commercial and experimental products have been introduced to improve cutaneous wound healing. This review discusses some of both acellular and cell-containing products used in the treatment of skin wounds.
皮肤替代和伤口愈合是医学领域中近期取得了许多进展的领域，但无论是市售产品还是目前实验研究中描述的产品，都无法完全替代天然的活皮肤。人们普遍认为，要愈合伤口，替代结缔组织基质（每个伤口的主要成分）是必要的。人工聚合物和天然聚合物都已被用于重建真皮。如今，胶原蛋白又被重新发现。胶原蛋白是细胞附着、生长和分化的天然基质，并促进细胞增殖和分化。一旦完成真皮重建，用体外扩增的表皮和自体断层皮片移植覆盖伤口表面就明显更容易，且成功几率更高。如今，已经推出了许多商业和实验产品来促进皮肤伤口愈合。本文综述了一些用于治疗皮肤伤口的无细胞和含细胞产品。
