噬菌体T4的结构与形态发生
Structure and morphogenesis of bacteriophage T4.
作者信息
Leiman P G, Kanamaru S, Mesyanzhinov V V, Arisaka F, Rossmann M G
机构信息
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, Indiana 47907-2054, USA.
出版信息
Cell Mol Life Sci. 2003 Nov;60(11):2356-70. doi: 10.1007/s00018-003-3072-1.
Bacteriophage T4 is one of the most complex viruses. More than 40 different proteins form the mature virion, which consists of a protein shell encapsidating a 172-kbp double-stranded genomic DNA, a 'tail,' and fibers, attached to the distal end of the tail. The fibers and the tail carry the host cell recognition sensors and are required for attachment of the phage to the cell surface. The tail also serves as a channel for delivery of the phage DNA from the head into the host cell cytoplasm. The tail is attached to the unique 'portal' vertex of the head through which the phage DNA is packaged during head assembly. Similar to other phages, and also herpes viruses, the unique vertex is occupied by a dodecameric portal protein, which is involved in DNA packaging.
噬菌体T4是最复杂的病毒之一。40多种不同的蛋白质构成了成熟的病毒体，它由一个包裹着172千碱基对双链基因组DNA的蛋白质外壳、一条“尾巴”和附着在尾巴末端的纤维组成。纤维和尾巴携带宿主细胞识别传感器，是噬菌体附着到细胞表面所必需的。尾巴还作为一个通道，用于将噬菌体DNA从头部输送到宿主细胞细胞质中。尾巴通过头部组装过程中噬菌体DNA被包装的独特“门户”顶点附着在头部。与其他噬菌体以及疱疹病毒类似，这个独特的顶点被一个十二聚体门户蛋白占据，该蛋白参与DNA包装。
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