Harper E Jean, Hackett Rachel M, Wilkinson Joy, Heaton Paul R
Waltham Centre for Pet Nutrition, Waltham-on-the-Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK.
J Am Vet Med Assoc. 2003 Nov 15;223(10):1436-42. doi: 10.2460/javma.2003.223.1436.
To investigate age-related variations in results of hematologic and plasma biochemical tests performed on dogs of 2 common breeds.
Prospective cohort study.
34 Beagles and 44 Labrador Retrievers.
Blood samples were collected throughout the dogs' lives; 589 samples were collected from the Beagles and 964 samples were collected from the Labrador Retrievers (age at the time of sample collection ranged from 22 days to 15 years). White blood cell and RBC counts; hemoglobin concentration; Hct; mean cell volume; mean cell hemoglobin concentration; alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities; and calcium, phosphorus, cholesterol, urea, protein, and albumin concentrations were measured.
For all tests, there were significant effects of age on test results. There was a significant interaction between age and breed for all tests except hemoglobin, albumin, and phosphorus concentrations.
Results suggested that there were age-related changes in hematologic and plasma biochemical test results in these 2 breeds of dogs. Changes were most evident during the first year of life, reflecting growth and maturation of the puppies. In some instances, values for puppies diverged markedly from those for adults, necessitating the use of age-specific reference ranges for the interpretation of clinical data.
研究对2种常见犬种进行血液学和血浆生化检测结果的年龄相关差异。
前瞻性队列研究。
34只比格犬和44只拉布拉多寻回犬。
在犬的整个生命过程中采集血样；从比格犬采集了589份样本，从拉布拉多寻回犬采集了964份样本（样本采集时的年龄范围为22天至15岁）。检测白细胞和红细胞计数、血红蛋白浓度、血细胞比容、平均红细胞体积、平均红细胞血红蛋白浓度、碱性磷酸酶、丙氨酸氨基转移酶和天冬氨酸氨基转移酶活性，以及钙、磷、胆固醇、尿素、蛋白质和白蛋白浓度。
对于所有检测，年龄对检测结果有显著影响。除血红蛋白、白蛋白和磷浓度外，所有检测中年龄与品种之间均存在显著交互作用。
结果表明，这2种犬种的血液学和血浆生化检测结果存在年龄相关变化。这些变化在生命的第一年最为明显，反映了幼犬的生长和成熟。在某些情况下，幼犬的值与成年犬的值明显不同，因此在解释临床数据时需要使用特定年龄的参考范围。
