Yaltirik M, Dedeoglu K, Bilgic B, Koray M, Ersev H, Issever H, Dulger O, Soley S
Department of Oral Surgery and Medicine, Faculty of Dentistry, Istanbul University, Capa, Istanbul, Turkey.
Oral Dis. 2003 Nov;9(6):284-6. doi: 10.1034/j.1601-0825.2003.00954.x.
The purpose of this in vivo study was to histopathologically evaluate the inflammatory reaction incited by Vicryl in rats and compare this material with various suture materials that are widely used in the clinic.
Four different suture materials, catgut, silk, polypropylene, and Vicryl were used in soft tissues of 32 Sprague-Dawley rats. Incisions performed were sutured by a standard technique. Eight rats were killed at the first, third, fifth, and seventh days. Histopathological evaluation of the en bloc samples was performed by determining the density of seven cell-types. A numerical grading from one to three was used. The data were statistically analysed by Kruskal-Wallis one way ANOVA and Dunn's tests.
Vicryl has produced the mildest tissue reaction among the test materials at all experimental periods (P<0.05). Total cell number value in Vicryl group was found to be significantly lower than the one in catgut group (P<0.05).
Under the conditions of this study, the results demonstrated that Vicryl as a suture material produced the mildest tissue reaction during early healing period.
本体内研究旨在通过组织病理学评估薇乔缝线在大鼠体内引发的炎症反应，并将该材料与临床广泛使用的各种缝合材料进行比较。
在32只Sprague-Dawley大鼠的软组织中使用四种不同的缝合材料，即肠线、丝线、聚丙烯缝线和薇乔缝线。采用标准技术对切口进行缝合。在第1、3、5和7天处死8只大鼠。通过测定七种细胞类型的密度对整块样本进行组织病理学评估。采用1至3的数字分级。数据通过Kruskal-Wallis单因素方差分析和邓恩检验进行统计学分析。
在所有实验阶段，薇乔缝线在受试材料中引发的组织反应最为轻微（P<0.05）。薇乔缝线组的总细胞数显著低于肠线组（P<0.05）。
在本研究条件下，结果表明薇乔缝线作为一种缝合材料在早期愈合阶段引发的组织反应最为轻微。
