Reilly S L, Ferrell R E, Kottke B A, Sing C F
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109-0618.
Am J Hum Genet. 1992 Dec;51(6):1311-24.
The influence of the apolipoprotein E (Apo E) polymorphism and gender on the regression relationships between each of nine plasma lipid and apolipoprotein traits (total cholesterol; ln triglycerides; high-density-lipoprotein cholesterol; apolipoproteins AI, AII, B, and CII; ln CIII; and ln E) and four concomitants (age, weight, waist-to-hip ratio, and smoking) was studied in 507 unrelated individuals representative of the adult population of Rochester, MN. Analyses are presented separately for females and males. Each lipid and apolipoprotein trait exhibited at least one Apo E genotype-specific regression relationship with the concomitants investigated in this study. In most cases the heterogeneity of regression was associated with differences between the epsilon 32 and epsilon 33 genotype. This study documents that the influence of Apo E genotype on average levels of plasma lipids and apolipoproteins varies among subdivisions of the population defined by age, body size, and smoking status.
在明尼苏达州罗切斯特市具有代表性的507名成年无关个体中，研究了载脂蛋白E（Apo E）基因多态性和性别对九种血浆脂质和载脂蛋白特征（总胆固醇；甘油三酯对数；高密度脂蛋白胆固醇；载脂蛋白AI、AII、B和CII；CIII对数；以及E对数）与四种伴随因素（年龄、体重、腰臀比和吸烟）之间回归关系的影响。分别对女性和男性进行了分析。每种脂质和载脂蛋白特征与本研究中调查的伴随因素均表现出至少一种Apo E基因型特异性回归关系。在大多数情况下，回归的异质性与ε32和ε33基因型之间的差异有关。这项研究表明，Apo E基因型对血浆脂质和载脂蛋白平均水平的影响在按年龄、体型和吸烟状况定义的人群亚组中有所不同。
