Akbari Omid, Stock Philippe, DeKruyff Rosemarie H, Umetsu Dale T
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305-5208, USA.
Curr Opin Immunol. 2003 Dec;15(6):627-33. doi: 10.1016/j.coi.2003.09.012.
Th2 cells play a critical role in the pathogenesis of allergy and asthma. However, the immunological mechanisms that downmodulate and protect against the development of these disorders are poorly understood. A spectrum of CD4(+) T cells, including Th3 cells, T(R) cells, CD4(+)CD25(+) cells and NKT cells play a critical role in regulating these diseases. A better understanding of the role of regulatory cells in allergic diseases may lead to the identification of novel therapeutic targets.
Th2细胞在过敏和哮喘的发病机制中起关键作用。然而，下调并预防这些疾病发生的免疫机制却鲜为人知。一系列CD4(+) T细胞，包括Th3细胞、T(R)细胞、CD4(+)CD25(+)细胞和自然杀伤T细胞（NKT细胞）在调节这些疾病中起关键作用。更好地理解调节性细胞在过敏性疾病中的作用可能会促成新治疗靶点的发现。
