调节性T细胞控制过敏性疾病和哮喘的发展。
Regulatory T cells control the development of allergic disease and asthma.
作者信息
Umetsu Dale T, Akbari Omid, Dekruyff Rosemarie H
机构信息
Division of Immunology and Allergy, Department of Pediatrics, Room G309, Stanford University, Stanford, CA 94305-5208, USA.
出版信息
J Allergy Clin Immunol. 2003 Sep;112(3):480-7; quiz 488.
The role of T(H)2 cells in the pathogenesis of allergy and asthma has been well described. However, the immunologic mechanisms that downmodulate and protect against the development of these disorders are poorly characterized. A spectrum of CD4+ T cells, including T(H)1 cells, T(H)3 cells, regulatory T cells, CD25+ T cells, and natural killer T cells might play a critical role in regulating these diseases and are discussed in this review.
辅助性T2细胞在过敏和哮喘发病机制中的作用已得到充分描述。然而，下调并预防这些疾病发生的免疫机制却鲜为人知。一系列CD4 + T细胞，包括辅助性T1细胞、辅助性T3细胞、调节性T细胞、CD25 + T细胞和自然杀伤T细胞，可能在调控这些疾病中发挥关键作用，本文将对此进行讨论。
Zotero 插件