Hojo K, Kumasaka Y, Nishiyama S, Higashihara T, Oku Y, Okada M, Kajiyama K
Dept. of Neurology, Kansai Rosai Hospital, Japan.
Gan To Kagaku Ryoho. 1992 Dec;19(14):2403-6.
A 75-year-old male who suffered from adenocarcinoma of lung cancer with multiple brain metastases, developed left hemiplegia. After diagnosis, he was treated with 4,000 cGy whole brain radiation, but soon after advanced lymphangitis carcinomatosa set in and his general condition deteriorated. He was administered carboplatin combination with etoposide and ifosfamide. Lymphangitis carcinomatosa disappeared, and the main tumor of lung and brain metastases were not growing. We recommended carboplatin for an old patient or one in poor condition, because it had less cytotoxicity and retained the same antitumor activity compared with cisplatin.
一名75岁男性，患有肺癌腺癌并伴有多处脑转移，出现了左侧偏瘫。诊断后，他接受了4000厘戈瑞的全脑放疗，但不久后发生了晚期癌性淋巴管炎，其一般状况恶化。他接受了卡铂联合依托泊苷和异环磷酰胺的治疗。癌性淋巴管炎消失，肺部主肿瘤和脑转移瘤没有生长。我们推荐对老年患者或状况较差的患者使用卡铂，因为与顺铂相比，它的细胞毒性较小且保留了相同的抗肿瘤活性。
