Cho Joon Ho, Kang Hyung Goo, Kim Seung Ho, Lee Hahn Shick, Lee Kyeong Ryong, Kang Hae Youn
Department of Emergency Medicine, Yonsei University College of Medicine, Seoul, Korea.
Korean J Gastroenterol. 2003 Oct;42(4):283-8.
BACKGROUNDS/AIMS: Gastrointestinal decompression by nasogastric or intestinal tubes developed in 1930s has been the only treatment modality for inoperable intestinal obstruction. We hypothesized that the octreotide, a potent inhibitor of intestinal secretion, has a therapeutic potential in intestinal obstruction.
Forty Sprague-Dawley rats were randomly assigned to four groups. The rats were subjected to complete or partial ileal obstruction. The treated rats received octreotide (100 microgram/kg) while the controls received the same quantity of saline every 12 hours for 24 or 48 hours. After 24 or 48 hours, the volumes of the small bowel contents were measured. The volumes of supernatant and the concentrations of electrolytes in the small bowel contents after centrifugation were also analyzed. The ileal segments proximal to obstruction were harvested, fixed, and stained, and the pathological changes were evaluated with mucosal damage scores.
There were no statistical differences in the volume and the electrolyte composition of intestinal fluid among the 4 groups. In the 48 hour complete obstruction group, the octreotide-treated rats showed statistically lower mucosal damage scores than the control rats (p<0.05).
Octreotide exerts mucosal protecting effect on the complete intestinal obstruction rat model.
背景/目的：20世纪30年代出现的经鼻胃管或肠管进行胃肠减压一直是不可手术治疗的肠梗阻的唯一治疗方式。我们推测，强效肠分泌抑制剂奥曲肽在肠梗阻治疗中具有潜在作用。
40只Sprague-Dawley大鼠被随机分为四组。对大鼠造成完全或部分回肠梗阻。治疗组大鼠每12小时接受奥曲肽（100微克/千克），而对照组每12小时接受等量生理盐水，持续24或48小时。24或48小时后，测量小肠内容物体积。还分析了离心后小肠内容物上清液体积和电解质浓度。收集梗阻近端的回肠段，固定并染色，用黏膜损伤评分评估病理变化。
四组之间肠液体积和电解质组成无统计学差异。在48小时完全梗阻组中，奥曲肽治疗的大鼠黏膜损伤评分显著低于对照组大鼠（p<0.05）。
奥曲肽对完全性肠梗阻大鼠模型具有黏膜保护作用。
