Gittes G K, Nelson M T, Debas H T, Mulvihill S J
Department of Surgery, University of California, San Francisco.
Am J Surg. 1992 Feb;163(2):231-3. doi: 10.1016/0002-9610(92)90107-3.
Small bowel obstruction is a common disorder in surgical practice. The major morbidity of bowel obstruction relates to intestinal distension and ischemia. We hypothesized that octreotide, a potent inhibitor of gut secretion, would reduce mortality in a mouse model of lethal small bowel obstruction. C57 mice were anesthetized with urethane and prepared with either proximal jejunal or distal ileal obstruction. After 8 hours, surviving mice were randomized to receive either octreotide (100 micrograms/kg) or saline subcutaneously every 8 hours. Octreotide significantly improved survival in mice with proximal obstruction by life table analysis. Mean survival increased from 31 +/- 3 to 41 +/- 4 hours. In distal obstruction, octreotide treatment resulted in a trend towards improved survival; however, this trend failed to reach statistical significance by life table analysis. The improvement in survival in this mouse model suggests that octreotide may be a valuable adjunct in the treatment of patients with small bowel obstruction.
小肠梗阻是外科临床实践中的一种常见病症。肠梗阻的主要发病情况与肠扩张和局部缺血有关。我们推测，一种强效的肠道分泌抑制剂——奥曲肽，能够降低致死性小肠梗阻小鼠模型的死亡率。将C57小鼠用氨基甲酸乙酯麻醉，并制备近端空肠梗阻或远端回肠梗阻模型。8小时后，存活的小鼠被随机分为两组，分别每8小时皮下注射一次奥曲肽（100微克/千克）或生理盐水。通过生存表分析，奥曲肽显著提高了近端梗阻小鼠的存活率。平均存活时间从31±3小时增加到了41±4小时。在远端梗阻模型中，奥曲肽治疗呈现出存活率提高的趋势；然而，通过生存表分析，这一趋势未达到统计学意义。该小鼠模型中存活率的提高表明，奥曲肽可能是治疗小肠梗阻患者的一种有价值的辅助药物。
