Lai Ting-I, Hwang Juey-Jen, Fang Cheng-Chung, Chen Wen-Jone
Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Republic of China.
Ann Emerg Med. 2003 Dec;42(6):759-62. doi: 10.1016/s0196-0644(03)00511-0.
Methylene 3, 4 dioxymethamphetamine (MDMA) has been gaining popularity as a recreational drug over the past few decades around the globe. Although once thought to be safer than its mother compound, amphetamine, several life-threatening adverse reactions have been reported. Among the cardiovascular toxicities documented, MDMA commonly causes various forms of arrhythmia and heart failure. However, MDMA-induced acute myocardial infarction is rarely reported. We report a case of acute myocardial infarction in a young man shortly after taking MDMA. Massive thrombosis over the right coronary artery was demonstrated by means of emergency angiography. After treatment with intravenous glycoprotein IIb/IIIa inhibitor and intracoronary urokinase infusion, the coronary artery was shown to be patent without any apparent stenotic lesions. The mechanism of MDMA-induced acute myocardial infarction was discussed.
亚甲二氧甲基苯丙胺（摇头丸）在过去几十年里作为一种消遣性药物在全球越来越受欢迎。尽管它曾被认为比其母体化合物苯丙胺更安全，但已报告了几种危及生命的不良反应。在已记录的心血管毒性中，摇头丸通常会导致各种形式的心律失常和心力衰竭。然而，摇头丸诱发的急性心肌梗死很少被报道。我们报告一例年轻男性在服用摇头丸后不久发生急性心肌梗死的病例。通过急诊血管造影显示右冠状动脉有大量血栓形成。经静脉注射糖蛋白IIb/IIIa抑制剂和冠状动脉内注入尿激酶治疗后，冠状动脉显示通畅，无明显狭窄病变。文中讨论了摇头丸诱发急性心肌梗死的机制。
