苯氧基除草剂、软组织肉瘤和非霍奇金淋巴瘤：队列研究和病例对照研究证据的系统评价
Phenoxy herbicides, soft-tissue sarcoma and non-Hodgkin lymphoma: a systematic review of evidence from cohort and case-control studies.
作者信息
Jayakody Nimeshi, Harris E Clare, Coggon David
机构信息
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
出版信息
Br Med Bull. 2015 Jun;114(1):75-94. doi: 10.1093/bmb/ldv008. Epub 2015 Mar 19.
Abstract
BACKGROUND
Phenoxy herbicides have been used widely in agriculture, forestry, parks and domestic gardens. Early studies linked them with soft-tissue sarcoma (STS) and non-Hodgkin lymphoma (NHL), but when last reviewed by the International Agency for Research on Cancer in 1986, the evidence for human carcinogenicity was limited.
SOURCES OF DATA
We searched Medline and Embase, looking for cohort or case-control studies that provided data on risk of STS and/or NHL in relation to phenoxy herbicides, and checked the reference lists of relevant publications for papers that had been missed.
AREAS OF AGREEMENT, AREAS OF CONTROVERSY: The extensive evidence is not entirely consistent, and a hazard of STS or NHL cannot firmly be ruled out. However, if there is a hazard, then absolute risks must be small.
GROWING POINTS, AREAS TIMELY FOR DEVELOPING RESEARCH: Extended follow-up of previously assembled cohorts may be the most efficient way of further reducing uncertainties.
摘要
背景
苯氧基除草剂已广泛应用于农业、林业、公园及家庭花园。早期研究将其与软组织肉瘤（STS）和非霍奇金淋巴瘤（NHL）联系起来，但1986年国际癌症研究机构上次审查时，其对人类致癌性的证据有限。
数据来源
我们检索了Medline和Embase，查找提供苯氧基除草剂与STS和/或NHL风险相关数据的队列研究或病例对照研究，并检查相关出版物的参考文献列表以查找遗漏的论文。
共识领域、争议领域：大量证据并不完全一致，不能完全排除STS或NHL的风险。然而，如果存在风险，那么绝对风险肯定很小。
发展点、适合开展研究的领域：对先前组建的队列进行延长随访可能是进一步减少不确定性的最有效方法。
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