Mircevová L, Simonová A
Acta Physiol Acad Sci Hung. 1976;48(1):51-7.
Anions exert an influence on the passive permeability of Na+ and K+ in erythrocytes. THE EFFECT ON Mg-ATPase activity has been studied in human erythrocytes. 40 mM bicarbonate increased the activity as compared to the effect of 40 mM chloride; 20 mM sulphate inhibited it. Salicylate acted first as an activator then as an inhibitor of Mg-ATPase; maximum activity was reached at 60 mM CONCENTRATION. Thiocyanate inhibited saponin-stimulated Mg-ATPase, Ki = 1.85 X 10(-2)M. The probable mechanisms of action of the above anions on Mg-ATPase and possible relation to passive permeability of Na+ and K+ ions are discussed.
阴离子对红细胞中Na+和K+的被动通透性有影响。已经对人类红细胞中Mg-ATP酶活性的影响进行了研究。与40 mM氯化物的作用相比，40 mM碳酸氢盐增加了该活性；20 mM硫酸盐则抑制了该活性。水杨酸盐首先作为Mg-ATP酶的激活剂，然后作为抑制剂；在60 mM浓度时达到最大活性。硫氰酸盐抑制皂角苷刺激的Mg-ATP酶，抑制常数Ki = 1.85×10(-2)M。讨论了上述阴离子对Mg-ATP酶的可能作用机制以及与Na+和K+离子被动通透性的可能关系。
