皮损内注射5-氟尿嘧啶治疗鳞状细胞癌。
Treatment of squamous cell carcinoma with intralesional 5-Fluorouracil.
作者信息
Morse Lisa G, Kendrick Christina, Hooper Deirdre, Ward Holly, Parry Edward
机构信息
Department of Dermatology, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA.
出版信息
Dermatol Surg. 2003 Nov;29(11):1150-3; discussion 1153. doi: 10.1046/j.1524-4725.2003.29355.x.
BACKGROUND
5-Fluorouracil (5-FU) has been used topically and intralesionally to treat lesions related to squamous cell carcinoma (SCC) such as actinic keratosis, Bowen's disease, and keratoacanthoma.
OBJECTIVE
We sought to determine whether intralesional 5-FU might be effective in treating a patient with SCC.
METHODS
A patient with SCC at the junction of the right alar crease and right nasolabial fold was treated with eight weekly injections of 5-FU, with doses ranging from 0.8 to 2.4 mL.
RESULTS
A repeat biopsy after the eighth treatment showed total clearance of the cancer, and the patient has remained free of recurrence during a 5-month follow-up period.
CONCLUSION
This modality may provide patients with SCC in cosmetically important locations or in areas that require complex surgery the advantage of a nonsurgical cure.
背景
5-氟尿嘧啶（5-FU）已被用于局部和病灶内治疗与鳞状细胞癌（SCC）相关的病变，如光化性角化病、鲍恩病和角化棘皮瘤。
目的
我们试图确定病灶内注射5-FU对治疗SCC患者是否有效。
方法
一名SCC患者，病变位于右鼻翼沟与右鼻唇沟交界处，每周注射一次5-FU，共八次，剂量为0.8至2.4毫升。
结果
第八次治疗后重复活检显示癌症完全清除，患者在5个月的随访期内未复发。
结论
这种治疗方式可为病变位于美容重要部位或需要复杂手术的SCC患者提供非手术治愈的优势。
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