嗜酒中毒中色氨酸代谢的研究。

Studies on tryptophan metabolism in ethylism.

作者信息

Allegri G, Allegri L, Costa C, De Antoni A, Strauch P

出版信息

Acta Vitaminol Enzymol. 1975;29(1-6):169-73.

Abstract

The urinary excretion of the metabolites "via kynurenine" was studied in a group of patients with chronic alcoholism after a L-tryptophan loading (100 mg/kg body-weight) with or without simultaneous administration of vitamin B6 or nicotinamide or both. In these subjects an abnormal tryptophan metabolism was obtained with excretion total mean values of 9 metabolites of 15.34% against 6.86% in healthy controls. The treatment with vitamin B6 or nicotinamide in 5 patients decreased the total average excretion from 14.41% to 9.47% and to 9.92% respectively without normalizing, however, the excretory pattern produced from the aminoacid loading. The simultaneous administration of these two vitamins in 9 chronic alcoholic men corrected completely the metabolic defect (from 15.34% to 6.55%).

摘要

在一组慢性酒精中毒患者中，研究了在给予L-色氨酸负荷（100mg/kg体重）时，无论是否同时给予维生素B6或烟酰胺或两者，代谢物“经由犬尿氨酸”的尿排泄情况。在这些受试者中，获得了异常的色氨酸代谢，9种代谢物的排泄总量平均值为15.34%，而健康对照组为6.86%。5例患者接受维生素B6或烟酰胺治疗后，总平均排泄量分别从14.41%降至9.47%和9.92%，然而，氨基酸负荷产生的排泄模式并未恢复正常。9名慢性酒精中毒男性同时给予这两种维生素后，完全纠正了代谢缺陷（从15.34%降至6.55%）。