溴氰菊酯对小鼠免疫系统的影响。

Effects of deltamethrin on the immune system in mice.

作者信息

Lukowicz-Ratajczak J, Krechniak J

机构信息

Medical Academy, Department of Toxicology, Gdańsk-Wrzeszcz, Poland.

出版信息

Environ Res. 1992 Dec;59(2):467-75. doi: 10.1016/s0013-9351(05)80049-0.

DOI:10.1016/s0013-9351(05)80049-0

PMID:1464294

Abstract

The influence of deltamethrin on the immune system in mice was investigated. Female BALB/c mice received deltamethrin in two daily oral doses; 6 mg/kg for 84 days and 15 mg/kg for 14 days. The humoral immune response in animals immunized with sheep red blood cells determined by agglutinin and hemagglutinin titer as well as by the number of plaque-forming cells producing IgM antibodies was significantly decreased. Also, the cell-mediated immune response assessed by alpha-naphthyl acetate esterase activity, by formation of EAC (erythrocyte-antibody-complement) rosettes, and by the footpad reaction test was hindered. A decrease in interleukin-1 activity was also ascertained. The obtained results indicate that deltamethrin exhibits an immunosuppressive effect.

摘要

研究了溴氰菊酯对小鼠免疫系统的影响。雌性BALB/c小鼠每日口服两次溴氰菊酯；84天内每日剂量为6mg/kg，14天内每日剂量为15mg/kg。通过凝集素和血凝素滴度以及产生IgM抗体的噬斑形成细胞数量来测定用绵羊红细胞免疫的动物的体液免疫反应，结果显示该反应显著降低。此外，通过α-萘乙酸酯酶活性、EAC（红细胞-抗体-补体）花环形成以及足垫反应试验评估的细胞介导免疫反应也受到了阻碍。还确定了白细胞介素-1活性的降低。所得结果表明溴氰菊酯具有免疫抑制作用。