Sharetskiĭ A N, Abramova M R, Zamulaeva I A, Kulish Iu S
Radiats Biol Radioecol. 1997 May-Jun;37(3):387-94.
Under the influence of the combined action of gamma irradiation (1 Gy, 1,15 Gy/min) and benzene the synergistic reduction of proportion and absolute content of B-cells and less expressed reduction of absolute content T-cells in spleen and lymph nodes was observed. In spleen the thymus-dependent humoral immune response was resistant to combined effect of irradiation and benzene, while in lymph nodes it was highly sensitive. The profound suppression of antibody formation in lymph nodes was characterized by synergism. It was accompanied by the block of specific recruitment of antigen sensitive cells within drained lymph nodes from migrating stream. The suppression of local immune response resulting from the combined effect of radiation and toxicants may be the cause of protective immunity disturbance.
在γ辐射（1 Gy，1.15 Gy/分钟）和苯的联合作用影响下，观察到脾脏和淋巴结中B细胞比例和绝对含量的协同降低以及T细胞绝对含量的较少表达降低。在脾脏中，胸腺依赖性体液免疫反应对辐射和苯的联合作用具有抗性，而在淋巴结中则高度敏感。淋巴结中抗体形成的深度抑制具有协同作用特征。它伴随着从迁移流中引流的淋巴结内抗原敏感细胞的特异性募集受阻。辐射和毒物联合作用导致的局部免疫反应抑制可能是保护性免疫紊乱的原因。
