Bogerts B, Lieberman J A, Ashtari M, Bilder R M, Degreef G, Lerner G, Johns C, Masiar S
Department of Psychiatry, Hillside Hospital Division of Long Island Jewish Medical Center, Albert Einstein College of Medicine, Glen Oaks, NY 11004.
Biol Psychiatry. 1993 Feb 15;33(4):236-46. doi: 10.1016/0006-3223(93)90289-p.
Volumes of the mesiotemporal structures (hippocampus-amygdala complex) were measured in 19 men who were chronic multiepisode schizophrenics and 18 age-matched healthy controls using T1-weighted contiguous coronal magnetic resonance images of 3.1-mm width. Using the level of the mammillary bodies as an anatomical landmark, the whole hippocampus-amygdala complex was divided into an anterior section (mainly containing amygdaloid tissue) and a posterior section (mainly containing the hippocampal formation). Total mesiotemporal tissue volume was reduced significantly in the patient group compared to controls (-11%), with significant reductions in both left (-20%) and right (-15%) hippocampal sections. Reduced limbic tissue volume was associated with increased severity of psychopathology. Severity of positive psychotic symptoms (Brief Psychiatric Rating Scale [BPRS] psychosis factor) was correlated significantly with right and left total mesiotemporal volumes (Spearman rho's = -0.61 p < 0.01). Negative symptom scores (BPRS anergia factor, Scale for Assessment of Negative Symptoms [SANS] global items) were not significantly correlated with any mesiotemporal tissue volumes. The data corroborate and extend previous findings of temporolimbic structure volume reduction in schizophrenia, and suggest that the positive psychotic symptoms of schizophrenia are associated with anatomic anomalies in mesiotemporal structure.
利用3.1毫米宽的T1加权连续冠状磁共振图像，对19名慢性多发作型精神分裂症男性患者和18名年龄匹配的健康对照者的中颞叶结构（海马体-杏仁核复合体）体积进行了测量。以乳头体水平作为解剖学标志，将整个海马体-杏仁核复合体分为前部（主要包含杏仁核组织）和后部（主要包含海马结构）。与对照组相比，患者组的中颞叶组织总体积显著减少（-11%），左侧（-20%）和右侧（-15%）海马体部分均显著减少。边缘系统组织体积减少与精神病理学严重程度增加相关。阳性精神病性症状的严重程度（简明精神病评定量表[BPRS]精神病因子）与左右中颞叶总体积显著相关（斯皮尔曼相关系数=-0.61，p<0.01）。阴性症状评分（BPRS无活力因子、阴性症状评定量表[SANS]总体项目）与任何中颞叶组织体积均无显著相关性。这些数据证实并扩展了先前关于精神分裂症颞叶边缘结构体积减少的研究结果，并表明精神分裂症的阳性精神病性症状与中颞叶结构的解剖异常有关。
