铁过载及其与人类癌症风险的关联：铁作为致癌金属的证据。

Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal.

作者信息

Huang Xi

机构信息

Department of Environmental Medicine, NYU Cancer Institute, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA.

出版信息

Mutat Res. 2003 Dec 10;533(1-2):153-71. doi: 10.1016/j.mrfmmm.2003.08.023.

DOI:10.1016/j.mrfmmm.2003.08.023

PMID:14643418

Abstract

Unlike arsenic, chromium, or nickel, the carcinogenicity of iron is still under debate. In this review, evidence for iron as a carcinogenic metal was summarized from epidemiological, animal, and cell culture studies. The role of iron in various cancers, such as colorectal cancer and liver cancer was presented. Recent advancements on the molecular mechanisms of iron carcinogenesis were also reviewed. These include: (1) iron autoxidation involving only Fe(2+)+O2 in oxidant formation in biological systems and its pH dependency; (2) activation of oxidative responsive transcription factors and pro-inflammatory cytokines; and (3) iron-induced hypoxia signaling.

摘要

与砷、铬或镍不同，铁的致癌性仍存在争议。在本综述中，我们从流行病学、动物和细胞培养研究中总结了铁作为致癌金属的证据。介绍了铁在各种癌症（如结直肠癌和肝癌）中的作用。还综述了铁致癌分子机制的最新进展。这些进展包括：（1）生物系统中仅涉及Fe(2+)+O2的铁自氧化在氧化剂形成中的作用及其对pH的依赖性；（2）氧化反应性转录因子和促炎细胞因子的激活；以及（3）铁诱导的缺氧信号传导。