Westrin Asa, Frii Karin, Träskman-Bendz Lil
Division of Psychiatry, Department of Clinical Neuroscience, Lund University, 221 85, Lund, Sweden.
Eur Psychiatry. 2003 Nov;18(7):350-5. doi: 10.1016/j.eurpsy.2003.07.004.
Previous research on hypothalamic-pituitary adrenal (HPA) axis-activity in suicide attempter research has shown conflicting outcomes. The design of the present study was to test the influence of personality disorders and concominant axis I diagnoses on the dexamethasone suppression diagnostic test by use of multiple regression analyses. The sample consisted of 184 patients with a recent suicide attempt and 42 healthy controls. As expected, the lowest pre- and postdexamethasone cortisol levels were found in patients with personality disorders axis II, cluster B as compared to the other patients. The results remained significant when analysed for covariance with DSM-III-R axis I diagnoses, age or sex. Whether these low cortisol levels are due to previous experience of extreme stressful events or long-lasting burden, or whether they may be a consequence of biogenetic or psychological predisposal of interest, remains to be elucidated. Axis I comorbidity needs to be further examined.
先前关于自杀未遂者下丘脑-垂体-肾上腺（HPA）轴活性的研究结果相互矛盾。本研究的设计目的是通过多元回归分析，检验人格障碍和伴发的轴I诊断对地塞米松抑制诊断试验的影响。样本包括184例近期有自杀未遂行为的患者和42名健康对照者。正如预期的那样，与其他患者相比，轴II B簇人格障碍患者的地塞米松给药前和给药后皮质醇水平最低。在对DSM-III-R轴I诊断、年龄或性别进行协方差分析时，结果仍然显著。这些低皮质醇水平是由于先前经历的极端应激事件或长期负担，还是可能是生物遗传或心理易感性的结果，仍有待阐明。轴I共病情况需要进一步研究。
