Norman W H, Keitner G I, Miller I W
J Affect Disord. 1985 Jul;9(1):97-101. doi: 10.1016/0165-0327(85)90015-1.
In this study we examined the relationship of psychopathology and personality dysfunction to neuroendocrine functioning. MMPI profiles were examined for 30 psychiatric inpatients with major depression who were suppressors (60%) and nonsuppressors (40%) on the dexamethasone suppression test. There were no differences between suppressors and nonsuppressors on any of the MMPI scales or on DSM-III Axis-II diagnosis. When subdivided according to T-score elevations above 70 on MMPI scales 4 and 6, or 4 and 9, 30% of the sample, however, met criteria for personality dysfunction. Furthermore, a significantly higher proportion of suppressors (50%) evidenced personality dysfunction than did the nonsuppressors (8%). This suggests that certain MMPI scales are able to identify a subgroup of depressed patients with personality disturbances who also have a hypothalamic-pituitary-adrenal dysfunction.
在本研究中，我们检验了精神病理学和人格功能障碍与神经内分泌功能之间的关系。对30名患有重度抑郁症的精神科住院患者的明尼苏达多相人格测验（MMPI）剖面图进行了检查，这些患者在地塞米松抑制试验中分别为抑制者（60%）和非抑制者（40%）。在任何MMPI量表或《精神疾病诊断与统计手册》第三版（DSM-III）轴II诊断方面，抑制者和非抑制者之间均无差异。然而，根据MMPI量表4和6或4和9上T分数高于70进行细分时，30%的样本符合人格功能障碍的标准。此外，抑制者（50%）出现人格功能障碍的比例明显高于非抑制者（8%）。这表明某些MMPI量表能够识别出一组患有个性障碍且同时存在下丘脑-垂体-肾上腺功能障碍的抑郁症患者。
