Skrtic D, Antonucci J M, Eanes E D, Eidelman N
American Dental Association Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, 100 Bureau Drive Stop 8546, Gaithersburg, MD 20899, USA.
Biomaterials. 2004 Mar-Apr;25(7-8):1141-50. doi: 10.1016/j.biomaterials.2003.08.001.
The objectives of this study were to prepare hybrid and surface-modified amorphous calcium phosphates (ACPs) as fillers for mineral-releasing dental composites, and determine whether the mechanical strength of the composites could be improved without decreasing their remineralization potential. ACP was hybridized with tetraethoxysilane or zirconyl chloride and surface-treated with 3-methacryloxypropoxytrimethoxy silane (MPTMS) or zirconyl dimethacrylate (ZrDMA). Composites fabricated with unmodified ACP (u-ACP), hybrid or surface-modified ACP filler and photo-activated Bis-GMA, TEGDMA and 2-hydroxyethyl methacrylate (HEMA) (BTH resin), Bis-GMA, TEGDMA, HEMA and MPTMS (BTHS resin) or Bis-GMA, TEGDMA, HEMA and ZrDMA (BTHZ resin) were tested for their remineralizing potential and biaxial flexure strength (BFS). Ion releases from all composites were significantly above the minimum necessary for reprecipitation of apatite. The BFS of unfilled polymers was not adversely affected by immersion in saline solutions. The BFS of BTH and BTHS composites deteriorated upon soaking. However, BTHZ composites were practically unaffected by exposure to saline solutions. Filler hybridization resulted in a modest, but significant, improvement in the BFS (up to 24%) of BTHZ composites. Heterogeneous distribution of the ACP on disk surfaces was detected by the FTIR microspectroscopy analyses. This might have been caused by uncontrolled aggregation of ACP particles that appeared to hinder interfacial filler/resin interactions and diminish the mechanical strength of composites.
本研究的目的是制备混合和表面改性的无定形磷酸钙（ACP）作为可释放矿物质的牙科复合材料的填料，并确定在不降低其再矿化潜力的情况下，复合材料的机械强度是否能够提高。将ACP与四乙氧基硅烷或氧氯化锆进行混合，并使用3-甲基丙烯酰氧基丙基三甲氧基硅烷（MPTMS）或二甲基丙烯酸氧锆（ZrDMA）进行表面处理。用未改性的ACP（u-ACP）、混合或表面改性的ACP填料以及光活化的双酚A双甲基丙烯酸缩水甘油酯（Bis-GMA）、三乙二醇二甲基丙烯酸酯（TEGDMA）和甲基丙烯酸2-羟乙酯（HEMA）（BTH树脂）、Bis-GMA、TEGDMA、HEMA和MPTMS（BTHS树脂）或Bis-GMA、TEGDMA、HEMA和ZrDMA（BTHZ树脂）制备的复合材料，对其再矿化潜力和双轴弯曲强度（BFS）进行了测试。所有复合材料的离子释放量均显著高于磷灰石再沉淀所需的最低量。未填充聚合物的BFS不受浸入盐溶液的不利影响。BTH和BTHS复合材料浸泡后BFS恶化。然而，BTHZ复合材料实际上不受盐溶液暴露的影响。填料混合使BTHZ复合材料的BFS有适度但显著的提高（高达24%）。通过傅里叶变换红外光谱显微镜分析检测到ACP在圆盘表面的不均匀分布。这可能是由于ACP颗粒的不受控制的聚集导致的，这种聚集似乎阻碍了填料/树脂界面相互作用，并降低了复合材料的机械强度。
