Blackburn Patricia, Lamarche Benoît, Couillard Charles, Pascot Agnès, Bergeron Nathalie, Prud'homme Denis, Tremblay Angelo, Bergeron Jean, Lemieux Isabelle, Després Jean Pierre
Québec Heart Institute, Laval Hospital Research Center, 2725 Chemin Ste-Foy, Pavilion Marguerite-D'Youville, 4th Floor, Ste-Foy, Que., Canada G1V 4G5.
Atherosclerosis. 2003 Dec;171(2):327-36. doi: 10.1016/j.atherosclerosis.2003.06.001.
Fasting hypertriglyceridemia has been reported to be predictive of an exaggerated triglyceride (TG) response to an oral fat load. Abdominal obesity has also been associated with postprandial hyperlipidemia. The objective of the present study was to quantify the contribution of abdominal obesity and fasting hypertriglyceridemia to the magnitude of postprandial lipemia. For that purpose, potential differences in postprandial TG-rich lipoprotein (TRL) levels were examined among men characterized by the absence/presence of the "hypertriglyceridemic waist" phenotype following a standardized breakfast with a high fat content (64% calories as fat). Sixty-nine men (mean age +/- S.D.: 45.1 +/- 10.5 years) were classified according to waist girth (< 90 or >/ or = 90 cm) and fasting TG concentrations (< 2.0 or > or = 2.0 mmol/l). Subjects characterized by "hypertriglyceridemic waist" (waist > or = 90 cm and fasting TG > or = 2.0 mmol/l) showed the highest TRL-TG concentrations (P < 0.0001) throughout the entire postprandial period (8 h) as well as elevated concentrations of apolipoprotein (apo) B-48 and apo B-100 in all TRL fractions (large, medium and small) compared to subjects with low fasting TG levels who had waist girth values either above or below 90 cm. These higher postprandial TRL-TG levels among carriers of the "hypertriglyceridemic waist" phenotype also led to significantly greater postprandial TG-total area under the curve (AUC) in total TRLs resulting mainly from the increased concentrations of large- and medium-sized TRLs. Furthermore, subjects characterized by the "hypertriglyceridemic waist" phenotype displayed higher fasting insulin concentrations and postprandial insulin AUC compared to men with low fasting plasma TG levels and low waist girth values. In conclusion, results of the present study indicate that postprandial hyperlipidemia is associated with the simultaneous presence of abdominal obesity and elevated fasting TG concentrations: a condition that we have described as the "hypertriglyceridemic waist" phenotype.
据报道，空腹高甘油三酯血症可预测口服脂肪负荷后甘油三酯（TG）反应过度。腹部肥胖也与餐后高脂血症有关。本研究的目的是量化腹部肥胖和空腹高甘油三酯血症对餐后血脂异常程度的影响。为此，在食用高脂肪含量（占热量的64%）的标准化早餐后，对具有/不具有“高甘油三酯血症腰围”表型的男性餐后富含TG的脂蛋白（TRL）水平的潜在差异进行了研究。69名男性（平均年龄±标准差：45.1±10.5岁）根据腰围（<90或≥90 cm）和空腹TG浓度（<2.0或≥2.0 mmol/l）进行分类。具有“高甘油三酯血症腰围”（腰围≥90 cm且空腹TG≥2.0 mmol/l）的受试者在整个餐后期间（8小时）显示出最高的TRL-TG浓度（P<0.0001），并且与空腹TG水平低且腰围值高于或低于90 cm的受试者相比，所有TRL组分（大、中、小）中的载脂蛋白（apo）B-48和apo B-100浓度均升高。“高甘油三酯血症腰围”表型携带者中这些较高的餐后TRL-TG水平也导致总TRL中餐后TG曲线下总面积（AUC）显著更大，这主要是由于大、中型TRL浓度增加所致。此外，与空腹血浆TG水平低且腰围值低的男性相比，具有“高甘油三酯血症腰围”表型的受试者显示出更高的空腹胰岛素浓度和餐后胰岛素AUC。总之，本研究结果表明，餐后高脂血症与腹部肥胖和空腹TG浓度升高同时存在有关：我们将这种情况描述为“高甘油三酯血症腰围”表型。
