血清阴性脊柱关节病中的细胞因子及其通过肿瘤坏死因子阻断的调节：简要报告及文献综述
Cytokines in the seronegative spondyloarthropathies and their modification by TNF blockade: a brief report and literature review.
作者信息
Keller C, Webb A, Davis J
机构信息
University of California San Francisco, San Francisco, California, USA.
出版信息
Ann Rheum Dis. 2003 Dec;62(12):1128-32. doi: 10.1136/ard.2003.011023.
Abstract
Rheumatoid arthritis (RA) is a disease well characterised by proinflammatory cytokine secretion (particularly tumour necrosis factor, interferon gamma, interleukin (IL) 1, and IL6). Less has been reported about the cytokine profiling in the spondyloarthropathies (SpA). Several trials suggest that, similar to RA, proinflammatory cytokines are globally expressed in the SpA. However, other studies report a down regulation of these cytokines in the SpA, with a relative anti-inflammatory polarisation (featuring increases in IL4, IL5, and IL10). This review summarises current published reports and the variation in cytokine data in the SpA. Additionally, results of cytokine profiles in patients with ankylosing spondylitis before and after treatment with etanercept are reported.
摘要
类风湿性关节炎（RA）是一种以促炎细胞因子分泌（特别是肿瘤坏死因子、干扰素γ、白细胞介素（IL）-1和IL-6）为显著特征的疾病。关于脊柱关节炎（SpA）中细胞因子谱的报道较少。多项试验表明，与RA相似，促炎细胞因子在SpA中普遍表达。然而，其他研究报告称，这些细胞因子在SpA中下调，呈现相对的抗炎极化（其特征是IL-4、IL-5和IL-10增加）。本综述总结了目前已发表的报告以及SpA中细胞因子数据的差异。此外，还报告了强直性脊柱炎患者在使用依那西普治疗前后的细胞因子谱结果。
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